WHOLE GENOME SEQUENCE ANALYSIS OF CAYO SANTIAGO RHESUS MACAQUES
Our lab at UPenn is developing techniques to combine linear mixed modeling (used in heritability analyses) with sparse regression (used in genome-wide association studies) to look for phenotype-genotype associations
Cayo Santiago is home to a free-ranging colony of rhesus macaques since 1938. The population is descended from 409 Indian-origin founders, including 40 adult males and 183 adult females.
Aim OneAlign whole genome sequences from population samples to the M. mulatta reference assembly
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Aim TwoIdentify single nucleotide
variants (SNVs) |
Aim ThreeIdentify structural
variants (SVs) |